Takeda A, Salmi M, Jalkanen S: “Lymph node lymphatic endothelial cells as multifaceted gatekeepers in the immune system.” Trends in Immunology 44: 72-86, 2023.


Hua Y, Vella G, Rambow F, Allen E, Antoranz Martinez A, Duhamel M, Takeda A, Jalkanen S, Junius S, Smeets A, Nittner D, Dimmeler S, Hehlgans T, Liston A, Bosisio FM, Floris G, Laoui D, Hollmén M, Lambrechts D, Merchiers P, Marine JC, Schlenner S, Bergers G: “Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop.” Cancer Cell 12: 1600-1618, 2022.

Losenkova K, Takeda A, Ragauskas S, Cerrada-Gimenez M, Vähätupa M, Kaja S, Paul ML, Schmies CC, Rolshoven G, Muller CE, Sandholm J, Jalkanen S, Kalesnykas G, Yegutkin GG: “CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity.” Cellular and Molecular Life Sciences 79, 2022.

Pöysti S, Toivonen R, Takeda A, Silojärvi S, Yatkin E, Miyasaka M, Hänninen A: “Infection with the entric pathogen C. rodentium promotes islet-specific autoimmunity by activating a lymphatic route from the gut to pancreatic lymph node.” Mucosal Immunology, 2022. 


Kobayashi D, Sugiura Y, Umemoto E, Takeda A, Ueta H, Hayasaka H, Matsuzaki S, Katakai T, Suematsu M, Hamachi I, Yegutkin GG, Salmi M, Jalkanen S, Miyasaka M: “Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes.” Frontiers in Immunology 12, 2021.

Virtakoivu R#, Rannikko J#, Viitala M#, Vaura F, Takeda A, Lonnberg T, Koivunen J, Jaakkola P, Pasanen A, Shetty S, de Jonge M, Robbrecht D, Ma YT, Skytta T, Minchom A, Jalkanen S, Karvonen MK, Mandelin J, Bono P, Hollmén M (#equally contributed authors): “Systemic blockade of Clever-1 elicits lymphocyte activation alongside checkpoint molecule downregulation in patients with solid tumors: Results from a phase I/II clinical trial.” Clinical Cancer Research, clincanres.4862, 2021. 

Tadayon S, Dunkel J, Takeda A, Eichin D, Virtakoivu R, Elima K, Jalkanen S, Hollmén M: “Lymphatic endothelial cell activation and dendritic cell transmigration is modified by genetic deletion of Clever-1.” Frontiers in Immunology, 12:602122, 2021. 


Eichin D, Pessia A, Takeda A, Laakkonen J, Bellmann L, Kankainen M, Imhof BA, Stoitzner P, Tang J, Salmi M#, Jalkanen S# (#equally contributed senior authors): “CD73 contributes to anti-inflammatory properties of afferent lymphatic endothelial cells in humans and mice.” European Journal of Immunology, 2020. doi: 10.1002/eji.201948432. 

Xiang M, Grosso RA, Takeda A, Pan J, Bekkhus T, Brulois K, Dermadi D, Nording S, Vanlandewijck M, Jalkanen S, Ulvmar MH#, Butcher EC# (#equally contributed senior authors): “A single-cell transcriptional roadmap of the mouse and human lymph node lymphatic vasculature.” Frontiers in Cardiovascular Medicine 7, 2020.

Takeda A, Jalkanen S: “Single-cell transcriptomics of human lymph node stroma.” STAR Protocols 1, 2020


Takeda A, Hollmén M, Dermadi D, Pan J, Brulois KF, Kaukonen R, Lönnberg T, Boström P, Koskivuo I, Irjala H, Miyasaka M, Salmi M, Butcher EC, Jalkanen S: “Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils.” Immunity 51: 561-572, 2019.

Tadayon S, Dunkel J, Takeda A, Halle O, Karikoski M, Gerke H, Rankari P, Virtakoivu R, Pabst O, Salmi M, Hollmén M, Jalkanen S: “Clever-1 contributes to lymphocyte entry into the spleen via the red pulp.” Science Immunology 4: eaat0297, 2019.


Takeda A, Sasaki N, Miyasaka M: “The molecular cues regulating immune cell trafficking.” Proceedings of the Japan Academy Ser B Physical and Biological Sciences 93: 183-195, 2017. 


Takeda A, Hossain MS, Rantakari P, Simmons S, Sasaki N, Salmi M, Jalkanen S, Miyasaka M: “Thymocytes in Lyve1-CRE/S1pr1f/f mice accumulate in the thymus due to cell-intrinsic loss of sphingosine-1-phosphate receptor expression.” Frontiers in Immunology, 7, 2016

Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E: “Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility.” eLIFE 5: e10561, 2016.

Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M: “Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.” International Immunology 28:283-292, 2016. 


Takeda A, Umemoto E, Miyasaka M: “Lysophosphatidic acid as a regulator of lymphocyte trafficking in the lymph nodes.” Translational Cancer Research 4: 537-543, 2015. 

Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Obata-Ninomiya K, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K: “The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells.” Immunity 42:279-293, 2015. 


Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K: “Generation of colonic IgA-secreting cells in the caecal patch.” Nature Communication 5:3704, 2014. 


Umemoto E, Takeda A, Jin S, Luo Z, Nakahogi N, Hayasaka H, Lee CM, Tanaka T, Miyasaka M: “Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions”. PLOS ONE 8:e83681, 2013. 

Bai Z#, Cai L#, Umemoto E#Takeda A# (#equally contributed first authors), Tohya K, Komai Y, Veeraveedu PT, Hata E, Sugiura Y, Kubo A, Suematsu M, Hayasaka H, Okudaira S, Aoki J, Tanaka T, Albers HM, Ovaa H, Miyasaka M: “Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis.” Journal of Immunology 190:2036-2048, 2013. 

Umemoto E, Hayasaka H, Bai Z, Cai L, Yonekura S, Peng X, Takeda A, Tohya K, Miyasaka M: “Novel regulators of lymphocyte trafficking across high endothelial venules.” Critical Reviews in Immunology 31:147-169, 2011.